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Selected Publications

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Kanan MK*, Sheehan PW*, Haines JN, Gomez PG, Dhuler A, Nadarajah CJ, Wargel ZM, Freeberg BM, Nelvagal HR, Izumo M, Takahashi JS, Cooper JD, Davis AA, Musiek ES (2023) Neuronal deletion of the circadian clock gene Bmal1 induces cell-autonomous dopaminergic neurodegeneration. JCI Insight, 9(2):e162771. *Co-first authors. CLICK HERE FOR FULL TEXT

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Lee J, Dimitry JM, Song JH, Son M, Sheehan PW, King MW, Travis Tabor G, Goo YA, Lazar MA, Petrucelli L, Musiek ES (2023) Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice. Nature Commun. 14(1):5197. CLICK HERE FOR FULL TEXT

Sheehan PW*, Nadarajah CJ*, Kanan MF, Patterson JN, Novotny B, Lawrence JH, King MW, Brase L, Inman CE, Yuede CM, Lee J, Patel TK, Harari O, Benitez BA, Davis AA, Musiek ES (2023) An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology. Neuron, S0896-6273(23)00379-3. *Co-first authors. CLICK HERE FOR FULL TEXT

McKee CA, Polino AJ, King MW, Musiek ES (2023) Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes. Proc Natl Acad Sci USA, 120(20):e2220551120. CLICK HERE FOR FULL TEXT


Musiek ES and Ju JE (2022) Targeting Sleep and Circadian Function in the Prevention of Alzheimer Disease. JAMA Neurol, 79(9):835-836. Editorial. CLICK HERE FOR FULL TEXT

Smith SK, Tran P, Madden KA, Boyd J, Braun R, Musiek ES, Ju YS (2022) Validation of blood-based transcriptomic circadian phenotyping in older adults. Sleep, 45(9):zsac148. CLICK HERE FOR FULL TEXT

McKee CA, Lee J, Cai Y, Saito T, Saido T, Musiek ES (2022) Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden Sci Rep, 12(1):1796. CLICK HERE FOR FULL TEXT

Musiek ES, Gomez-Isla T, Holtzman DM (2021) Aducanumab for Alzheimer disease: the amyloid hypothesis moves from bench to bedside. J Clin Invest, 131(20):e154889. CLICK HERE FOR FULL TEXT


Musiek ES and Bennett DA (2021) Aducanumab and the "post-amyloid" era of Alzheimer research? Neuron, 109(19):3045-3047. Editorial.

Basak JM, Ferreiro, Cohen LS, Sheehan PW, Nadarajah CJ, Kanan MF, Sukhum KV, Dantas G, Musiek ES (2021) Bacterial sepsis increases hippocampal fibrillar amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease. Neurobiol Dis, 152:105292. CLICK HERE FOR FULL TEXT

Lananna BV, McKee CA, King MW, Del-Aguila JL, Dimitry JM, Farias FHG, Nadarajah CJ, Xiong DD, Guo C, Cammack AJ, Elias JA, Zhang J, Cruchaga C, Musiek ES (2020) Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis. Sci Transl Med, 12: eaax3519. CLICK HERE FOR FULL TEXT

Griffin P, Sheehan PW, Dimitry JM, Guo C, Kanan MF, Lee J, Zhang J, Musiek ES (2020) REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis. eLife, 9:e58765. CLICK HERE FOR FULL TEXT


Sheehan PW, Musiek ES (2020) Evaluating Circadian Dysfunction in Mouse Models of Alzheimer's Disease: Where Do We Stand? Front Neurosci, 14:703. CLICK HERE FOR FULL TEXT

Lananna BV, Musiek ES (2020) The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration. Neurobiol Dis, 139:104832. CLICK HERE FOR FULL TEXT

Lee J, Kim DE, Griffin P, Sheehan PW, Kim DH, Musiek ES, Yoon SY (2020) Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer's disease. Aging Cell, 19(2):e13078. CLICK HERE FOR FULL TEXT

McKee CA, Lananna BV, Musiek ES (2020) Circadian regulation of astrocyte function: implications for Alzheimer's disease. Cell Mol Life Sci, 6:1049-1058.

Griffin P, Dimitry JM, Sheehan PW, Lananna BV, Guo C, Robinette ML, Hayes ME, Cedeño MR, Nadarajah CJ, Ezerskiy LA, Colonna M, Zhang J, Bauer AQ, Burris TP, Musiek ES. (2019) Circadian clock protein Rev-erbα regulates neuroinflammation. Proc Natl Acad Sci USA116:5102-5107. CLICK HERE FOR FULL TEXT

Leng Y, Musiek ES, Hu K, Cappuccio FP, Yaffe K. (2019) Association between circadian rhythms and neurodegenerative diseases. Lancet Neurol, 18:307-318. CLICK HERE FOR FULL TEXT

Lananna BV, Nadarajah CJ, Izumo M, Cedeño MR, Xiong DD, Dimitry J, Tso CF, McKee CA, Griffin P, Sheehan PW, Haspel JA, Barres BA, Liddelow SA, Takahashi JS, Karatsoreos IN, and Musiek ES (2018) Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1. Cell Rep, 25::1-9.e5. CLICK HERE FOR FULL TEXT

Kress GJ, Liao FDimitry JCedeno MRFitzGerald GAHoltzman DM, and Musiek ES (2018) Regulation of amyloid-β dynamics and pathology by the circadian clock. J Exp Med, 215:1059-1068. PMC5881473.  CLICK HERE FOR FULL TEXT



Musiek ES, Bhimasani M, Zangrilli MA, Morris JC, Holtzman DM, and Ju YS (2018) Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease. JAMA Neurol. 75:582-590. CLICK HERE FOR FULL TEXT

Musiek ES (2017) Circadian Rhythms in AD pathogenesis: A Critical Appraisal. Curr Sleep Med Rep, 3:85-92. PMC5754029. CLICK HERE FOR FULL TEXT


Musiek ES and Holtzman DM (2016) Mechanisms linking circadian clocks, sleep, and neurodegeneration. Science, 354: 1004-8. DOI: 10.1126/science.aah4968.  CLICK HERE FOR FULL TEXT

Day GS*, Musiek ES*, Roe CM, Norton J, Goate AM, Cruchaga C, Cairns NJ, Morris JC (2016) Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study. JAMA Neurol,  Jul 25. doi: 10.1001/jamaneurol.2016.1236.  *co-first authors.

Musiek ES, Xiong DD, Patel T, Sasaki Y, Wang Y, Bauer AQ, Singh R, Finn SL, Culver JP, Milbrandt J, Holtzman DM (2016) Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy. Ann Clin Transl Neurol, 5:314-30. CLICK FOR FULL TEXT

Yang G, Chen L, Grant GR, Paschos G, Song WL, Musiek ES, Lee V, McLoughlin SC, Grosser T, Cotsarelis G, FitzGerald GA (2016) Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival. Sci Transl Med, 8:324ra16. PMC4870001. CLICK HERE FOR FULL TEXT


Musiek ES and Holtzman DM (2015) Three dimensions of the amyloid hypothesis: time, space and 'wingmen'. Nat. Neurosci, 18:800-6. PMC4445458. CLICK FOR FULL TEXT


Musiek ES (2015)  Circadian clock disruption in neurodegenerative diseases: cause and effect? Front Pharmacol. 6:29; doi: 10.3389/fphar.2015.00029. CLICK FOR FULL TEXT


Musiek ES, Xiong DD, Holtzman DM (2015) Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease. Exp. Mol. Med. 47:e148. doi: 10.1038/emm.2014.12.  CLICK FOR FULL TEXT


Musiek ES, Lim MM, Yang G, Bauer AQ, Qi, L, Lee, Y, Roh, JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, Weaver DR, Holtzman DM, FitzGerald GA (2013) Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest, 123; 5389-400. PMC3859381.  CLICK FOR FULL TEXT











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