Selected Recent Publications

Griffin P, Dimitry JM, Sheehan PW, Lananna BV, Guo C, Robinette ML, Hayes ME, Cedeño MR, Nadarajah CJ, Ezerskiy LA, Colonna M, Zhang J, Bauer AQ, Burris TP, Musiek ES. (2019) Circadian clock protein Rev-erbα regulates neuroinflammation. Proc Natl Acad Sci USA116:5102-5107.

Leng Y, Musiek ES, Hu K, Cappuccio FP, Yaffe K. (2019) Association between circadian rhythms and neurodegenerative diseases. Lancet Neurol, 18:307-318

Lananna BV, Nadarajah CJ, Izumo M, Cedeño MR, Xiong DD, Dimitry J, Tso CF, McKee CA, Griffin P, Sheehan PW, Haspel JA, Barres BA, Liddelow SA, Takahashi JS, Karatsoreos IN, and Musiek ES (2018) Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1. Cell Rep, 25::1-9.e5. CLICK HERE FOR FULL TEXT

Kress GJ, Liao FDimitry JCedeno MRFitzGerald GAHoltzman DM, and Musiek ES (2018) Regulation of amyloid-β dynamics and pathology by the circadian clock. J Exp Med, 215:1059-1068. PMC5881473.  CLICK HERE FOR FULL TEXT

 

 

Musiek ES, Bhimasani M, Zangrilli MA, Morris JC, Holtzman DM, and Ju YS (2018) Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease. JAMA Neurol. 75:582-590.

 

Musiek ES (2017) Circadian Rhythms in AD pathogenesis: A Critical Appraisal. Curr Sleep Med Rep, 3:85-92. PMC5754029. CLICK HERE FOR FULL TEXT

 

Musiek ES and Holtzman DM (2016) Mechanisms linking circadian clocks, sleep, and neurodegeneration. Science, 354: 1004-8. DOI: 10.1126/science.aah4968.  CLICK HERE FOR FULL TEXT

Day GS*, Musiek ES*, Roe CM, Norton J, Goate AM, Cruchaga C, Cairns NJ, Morris JC (2016) Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study. JAMA Neurol,  Jul 25. doi: 10.1001/jamaneurol.2016.1236.  *co-first authors.

Musiek ES, Xiong DD, Patel T, Sasaki Y, Wang Y, Bauer AQ, Singh R, Finn SL, Culver JP, Milbrandt J, Holtzman DM (2016) Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy. Ann Clin Transl Neurol, 5:314-30. CLICK FOR FULL TEXT

Yang G, Chen L, Grant GR, Paschos G, Song WL, Musiek ES, Lee V, McLoughlin SC, Grosser T, Cotsarelis G, FitzGerald GA (2016) Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival. Sci Transl Med, 8:324ra16. PMC4870001. CLICK HERE FOR FULL TEXT

 

Musiek ES and Holtzman DM (2015) Three dimensions of the amyloid hypothesis: time, space and 'wingmen'. Nat. Neurosci, 18:800-6. PMC4445458. CLICK FOR FULL TEXT

 

Musiek ES (2015)  Circadian clock disruption in neurodegenerative diseases: cause and effect? Front Pharmacol. 6:29; doi: 10.3389/fphar.2015.00029. CLICK FOR FULL TEXT

 

Musiek ES, Xiong DD, Holtzman DM (2015) Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease. Exp. Mol. Med. 47:e148. doi: 10.1038/emm.2014.12.  CLICK FOR FULL TEXT

 

 

Musiek ES, Lim MM, Yang G, Bauer AQ, Qi, L, Lee, Y, Roh, JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, Weaver DR, Holtzman DM, FitzGerald GA (2013) Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest, 123; 5389-400. PMC3859381.  CLICK FOR FULL TEXT

Musiek ES and FitzGerald GA (2013) Molecular Clocks in Pharmacology.  Handb Exp Pharmacol. 2013; 217: 243–260. CLICK FOR FULL TEXT.

 

Chen Y, Wolk DA, Reddin JS, Korczykowski M, Martinez PM, Musiek ES, Newberg AB, Julin P, Arnold SE, Greenberg JH, Detre JA (2011) Voxel level Comparison Of Arterial Spin Labeled Perfusion MRI And FDG-PET In Alzheimer’s Disease.  Neurology. 77:1977-85.  PMC3235355

Musiek ES, Chen Y, Korczykowski M, Saboury B, Martinez PM, Reddin JS, Alavi A, Newberg AB, Julin P, Arnold SE, Detre JA (2011) Direct Comparison of FDG-PET and ASL-MRI in Alzheimer’s Disease.  Alzheimer Dement. 8:51-9. PMC3264701

 

 

 

 

Musiek ES, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, Blackwell TS, Montine TJ, Milne GL, McLaughlin B, Morrow JD (2008)  Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. J. Biol. Chem., 283: 19927-35. PMC2459280.

 

Musiek ES, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, Blackwell TS, Montine TJ, Milne GL, McLaughlin B, Morrow JD (2008)  Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. J. Biol. Chem., 283: 19927-35. PMC2459280.

 

Milne GL, Sanchez SC, Musiek ES, Morrow JD (2007). Quantification of F2-isoprostanes as a biomarker of oxidative stress. Nature Protocols, 2; 221-6

 

Musiek ES, Breeding RS, Milne GL, Morrow JD, McLaughlin B (2006).  Cyclopentenone isoprostanes are novel products of lipid oxidation which enhance neurodegeneration. J. Neurochem., 97; 1301-13.

 

Musiek ES, Milne GL, Everhart  MB, Wang, D, Backlund MG, DuBois RN,  Blackwell TN, Vidari G, Zanoni G, Morrow JD (2005)  Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages.  J. Biol. Chem., 280; 35562-70

 

 

 

 

 

 

Selected Older Publications