Selected Recent Publications

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Basak JM, Ferreiro, Cohen LS, Sheehan PW, Nadarajah CJ, Kanan MF, Sukhum KV, Dantas G, Musiek ES (2021) Bacterial sepsis increases hippocampal fibrillar amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease. Neurobiol Dis, 5 February 2021, 105292. CLICK HERE FOR FULL TEXT

Lananna BV, McKee CA, King MW, Del-Aguila JL, Dimitry JM, Farias FHG, Nadarajah CJ, Xiong DD, Guo C, Cammack AJ, Elias JA, Zhang J, Cruchaga C, Musiek ES (2020) Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis. Sci Transl Med, 12: eaax3519. CLICK HERE FOR FULL TEXT

Griffin P, Sheehan PW, Dimitry JM, Guo C, Kanan MF, Lee J, Zhang J, Musiek ES (2020) REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis. eLife, 9:e58765. CLICK HERE FOR FULL TEXT


Sheehan PW, Musiek ES (2020) Evaluating Circadian Dysfunction in Mouse Models of Alzheimer's Disease: Where Do We Stand? Front Neurosci, 14:703. CLICK HERE FOR FULL TEXT

Lananna BV, Musiek ES (2020) The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration. Neurobiol Dis, 139:104832. CLICK HERE FOR FULL TEXT

Lee J, Kim DE, Griffin P, Sheehan PW, Kim DH, Musiek ES, Yoon SY (2020) Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer's disease. Aging Cell, 19(2):e13078. CLICK HERE FOR FULL TEXT

McKee CA, Lananna BV, Musiek ES (2020) Circadian regulation of astrocyte function: implications for Alzheimer's disease. Cell Mol Life Sci, 6:1049-1058.

Griffin P, Dimitry JM, Sheehan PW, Lananna BV, Guo C, Robinette ML, Hayes ME, Cedeño MR, Nadarajah CJ, Ezerskiy LA, Colonna M, Zhang J, Bauer AQ, Burris TP, Musiek ES. (2019) Circadian clock protein Rev-erbα regulates neuroinflammation. Proc Natl Acad Sci USA116:5102-5107. CLICK HERE FOR FULL TEXT

Leng Y, Musiek ES, Hu K, Cappuccio FP, Yaffe K. (2019) Association between circadian rhythms and neurodegenerative diseases. Lancet Neurol, 18:307-318. CLICK HERE FOR FULL TEXT

Lananna BV, Nadarajah CJ, Izumo M, Cedeño MR, Xiong DD, Dimitry J, Tso CF, McKee CA, Griffin P, Sheehan PW, Haspel JA, Barres BA, Liddelow SA, Takahashi JS, Karatsoreos IN, and Musiek ES (2018) Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1. Cell Rep, 25::1-9.e5. CLICK HERE FOR FULL TEXT

Kress GJ, Liao FDimitry JCedeno MRFitzGerald GAHoltzman DM, and Musiek ES (2018) Regulation of amyloid-β dynamics and pathology by the circadian clock. J Exp Med, 215:1059-1068. PMC5881473.  CLICK HERE FOR FULL TEXT



Musiek ES, Bhimasani M, Zangrilli MA, Morris JC, Holtzman DM, and Ju YS (2018) Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease. JAMA Neurol. 75:582-590.

Musiek ES (2017) Circadian Rhythms in AD pathogenesis: A Critical Appraisal. Curr Sleep Med Rep, 3:85-92. PMC5754029. CLICK HERE FOR FULL TEXT


Musiek ES and Holtzman DM (2016) Mechanisms linking circadian clocks, sleep, and neurodegeneration. Science, 354: 1004-8. DOI: 10.1126/science.aah4968.  CLICK HERE FOR FULL TEXT

Day GS*, Musiek ES*, Roe CM, Norton J, Goate AM, Cruchaga C, Cairns NJ, Morris JC (2016) Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study. JAMA Neurol,  Jul 25. doi: 10.1001/jamaneurol.2016.1236.  *co-first authors.

Musiek ES, Xiong DD, Patel T, Sasaki Y, Wang Y, Bauer AQ, Singh R, Finn SL, Culver JP, Milbrandt J, Holtzman DM (2016) Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy. Ann Clin Transl Neurol, 5:314-30. CLICK FOR FULL TEXT

Yang G, Chen L, Grant GR, Paschos G, Song WL, Musiek ES, Lee V, McLoughlin SC, Grosser T, Cotsarelis G, FitzGerald GA (2016) Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival. Sci Transl Med, 8:324ra16. PMC4870001. CLICK HERE FOR FULL TEXT


Musiek ES and Holtzman DM (2015) Three dimensions of the amyloid hypothesis: time, space and 'wingmen'. Nat. Neurosci, 18:800-6. PMC4445458. CLICK FOR FULL TEXT


Musiek ES (2015)  Circadian clock disruption in neurodegenerative diseases: cause and effect? Front Pharmacol. 6:29; doi: 10.3389/fphar.2015.00029. CLICK FOR FULL TEXT


Musiek ES, Xiong DD, Holtzman DM (2015) Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease. Exp. Mol. Med. 47:e148. doi: 10.1038/emm.2014.12.  CLICK FOR FULL TEXT



Musiek ES, Lim MM, Yang G, Bauer AQ, Qi, L, Lee, Y, Roh, JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, Weaver DR, Holtzman DM, FitzGerald GA (2013) Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest, 123; 5389-400. PMC3859381.  CLICK FOR FULL TEXT

Musiek ES and FitzGerald GA (2013) Molecular Clocks in Pharmacology.  Handb Exp Pharmacol. 2013; 217: 243–260. CLICK FOR FULL TEXT.


Chen Y, Wolk DA, Reddin JS, Korczykowski M, Martinez PM, Musiek ES, Newberg AB, Julin P, Arnold SE, Greenberg JH, Detre JA (2011) Voxel level Comparison Of Arterial Spin Labeled Perfusion MRI And FDG-PET In Alzheimer’s Disease.  Neurology. 77:1977-85.  PMC3235355

Musiek ES, Chen Y, Korczykowski M, Saboury B, Martinez PM, Reddin JS, Alavi A, Newberg AB, Julin P, Arnold SE, Detre JA (2011) Direct Comparison of FDG-PET and ASL-MRI in Alzheimer’s Disease.  Alzheimer Dement. 8:51-9. PMC3264701